rofida albash
* 
, Aly A. Abdelbary, Hanan refai, mohamed nabarawi
Abstract
Olmesartan medoxomil (OLM), a scarce water soluble hypertension medication with 26% oral bioavailability, was to be encapsulated in PEGylated nanostructured lipid carriers (PNLCs) for transdermal distribution. Tween 80 or sodium deoxycholate stabilized the PNLCs, which were made up of liquid lipid including a mixture of medium chain triglycerides (labrasol and labrafil) and solid lipid (compritol and tristearin). Hot melt emulsification, high-speed stirring, and ultrasonication were used to create PNLCs. To distinguish the effects of formulation independent variables on entrapment efficiency %, particle size, polydispersity index, zeta potential, and amount of drug released after 6 hours (Q6h), a 24 complete factorial design using Design Expert® software was created.For additional research, the formula (PNLC16) with the best requirements was chosen. When compared to OLM solution, PNLC16 permeation was more potent when done ex vivo using both shed snake and rat skin. Histopathological analysis demonstrated that the topically administered PNLCs were safe. Pharmacodynamic research further demonstrated PNLC16's superiority over commercial oral pills in terms of long-lasting effects. All things considered, the results showed that PNLC16 would be a viable vehicle for OLM transdermal delivery.